History of Gemcitabine

  • Gemcitabine (Gemzar) falls under the nucleoside analog family of medication, acts in order to block the creation of new DNA, which results in the death of cells.
  • Foremost, during the early 1980s it was synthesized in Larry Hertel's lab at Eli Lilly and Company. Gemcitabine was intended as an antiviral medication, but preclinical testing demonstrated that it destroyed leukemia cells in vitro.
  • In the early 1990s this medication was studied in the clinical trials. The trial of pancreatic cancer found that this agent increased the 1 year survival time significantly.
  • In the year of 1995, Gemcitabine's approval in the UK took place and in the year of 1996 it was approved by the Food and Drug Administration in order to treat pancreatic cancers. 
  • In the year of 1998, gemcitabine 200 mg received Food and Drug Administration approval in order to treat non-small cell lung cancer and in the year of 2004 it was approved for treating the metastatic breast cancer.
  • In the year of 2008, European labels were harmonized by the EMA.
  • In the year of 2013, gemcitabine's US patents were set to expire and in the year of 2009 its European patents as well.
  • In the year of 2009, in Europe, the first generic was launched, and patent challenges were mounted in the United States which led to invalidation of a key Lilly patent on its method to manufacture the medication.
  • In the year of 2010 in the US, the generic companies started selling the drug when the patent regarding the chemical itself was out-dated. 
  • The gemcitabine price is around 2250 INR for a supply of vial of 1 injection, depending on the wholesaler/pharmacy you visit. Any WHO-GDP & ISO certified pharmaceutical wholesaler company would be best to buy Gemcitabine.

Comments

  1. MATINA13 August 2021 at 21:12

    I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
    liver already present. I started on antiviral medications which
    reduced the viral load initially. After a couple of years the virus
    became resistant. I started on HEPATITIS B Herbal treatment from
    ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
    treatment totally reversed the virus. I did another blood test after
    the 6 months long treatment and tested negative to the virus. Amazing
    treatment! This treatment is a breakthrough for all HBV carriers.

    ReplyDelete

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