History of Daratumumab

  • Daratumumab (Darzalex) falls under the anti-cancer medication. It is involved in order to bind to the CD38, which is overexpressed in the multiple myeloma cells.
  • It was originated by Genmab, but it is currently being jointly developed by Genmab along with the J&J subsidiary named Janssen Biotech, which acquired the global commercialization rights to the Daratumumab from Genmab.
  • In the month of August, 2012, Janssen Biotech announced the agreement of Global License and Development for investigational anti cancer agent daratumumab. 
  • In the month of May, 2013, daratumumab received breakthrough therapy designation in the double refractory MM from the U.S. FDA. 
  • In the month of February, 2015, Genmab has announced the preliminary outcomes in phase-II study of daratumumab in the double refractory multiple myeloma.
  • In the month of June, 2015,  Janssen initiated the rolling submission of BLA for daratumumab in order to treat patients with multiple myeloma. 
  • In the month of September 2015, the FDA granted priority review to Janssen for daratumumab as a treatment option for MM (Multiple Myeloma). 
  • In the month of November, 2015, the FDA approved daratumumab in order to treat patients with previously treated multiple myeloma. 
  • In the month of November, 2016, the FDA approved daratumumab together with two standard of care regimens in order to treat patients with multiple myeloma who have taken at least 1 prior therapy. 
  • In the month of June, 2017, the FDA approved daratumumab together with pomalidomide and dexamethasone for patients with RRMM (Relapsed/Refractory Multiple Myeloma). 
  • In the month of May, 2018, the FDA approved daratumumab for newly diagnosed patients with MM who are basically the transplant ineligible. 
  • In the month of February, 2019, the FDA approved daratumumab split-dosing regimen. 
  • In the month of June, 2019, the FDA approved daratumumab together with lenalidomide and dexamethasone for newly diagnosed multiple myeloma patients who are basically transplant ineligible. 
  • In the month of September, 2019 the FDA approved daratumumab combination regimen for the newly diagnosed, transplant eligible multiple myeloma patients. 
  • In the month of May, 2020, the FDA approved daratumumab and hyaluronidase in order to treat patients with Multiple Myeloma. 
  • In the month of August, 2020, the FDA approved a new carfilzomib combination regimen together with daratumumab and dexamethasone in both once and twice weekly dosing regimens. 
  • The daratumumab cost in india is around 75,000 INR for a supply of vial of one injection, depending on the pharmacy/wholesaler you visit. Any WHO-GDP & ISO certified pharmaceutical wholesaler company would be best to buy daratumumab. 

Comments

  1. MATINA13 August 2021 at 23:01

    I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
    liver already present. I started on antiviral medications which
    reduced the viral load initially. After a couple of years the virus
    became resistant. I started on HEPATITIS B Herbal treatment from
    ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
    treatment totally reversed the virus. I did another blood test after
    the 6 months long treatment and tested negative to the virus. Amazing
    treatment! This treatment is a breakthrough for all HBV carriers.

    ReplyDelete

Post a Comment

Popular posts from this blog

Buy Trodelvy sacituzumab govitecan-hziy in India

  Trodelvy Overview: Trodelvy is widely prescribed by Oncologists for the treatment of patients with HR+/HER2- Metastatic Breast Cancer, Metastatic Triple-Negative Breast Cancer (mTNBC), and Metastatic Urothelial Cancer (mUC). It is considered a promising treatment option for those who are not ideal candidates for some conventional therapies. Developed by Immunomedics, Trodelvy 180 mg and Trodelvy 200 mg are two available commercial strengths. Worldwide, Trodelvy is promoted and facilitated by Gilead Sciences. Trodelvy is first approved on 22 April 2020. It is given by intravenous (IV) infusion by a health specialist. The medication received its (European Medicines Agency) EMA approval in October 2021. Trodelvy 180 mg and 200 mg injections are yet to be approved in India. The cost of Trodelvy in India usually depends on international factors. Buy Trodelvy from a Reliable Source: Many suppliers who are not authorized to handle or supply life-saving medicines such as Trodelvy found ...
Read more

Lenvatinib Medication Guide

Lenvatinib is recommended for treating patients with locally recurrent, progressive, metastatic, radioactive iodine-refractory differentiated thyroid cancer (RAI-refractory DTC), together with everolimus for advanced renal cell carcinoma and for hepatocellular carcinoma.  Here are a few important points for patients before taking Lenvatinib:- Female patients who are able to become pregnant must use an effective method of birth control while on the treatment with lenvatinib and for at least 2 weeks after its last dose. Discuss with your doctor about the birth control methods you can use during this time. Lenvatinib is taken at the same time each and every day. If a patient misses any dose, and it cannot be consumed within 12 hours, then that dose must be skipped and the next dose should be consumed at the usual time of administration. The recommended dose is lenvatinib 24 mg (two lenvatinib 10 mg capsules and one lenvatinib 4 mg capsule) orally, taken once in a day, either with or...
Read more

Difference Between Multiple Myeloma And Leukemia

Image
What is multiple myeloma:  This is also known as plasma cell myeloma or Kahler's disease. It is a cancer in plasma cells that typically produce antibodies. When there is only one tumor present it is called as plasmacytoma and when more than one then called as multiple myeloma. The main cause of myeloma is unknown but the major risk factors are obesity,  inheritance chemicals, radiation, etc. With the effect of cancer, there is an abnormality in plasma cells that produces abnormal antibodies that can cause kidney problems. At the initial stage, there is no sign and symptoms but with the advancement of time bone pain, bleeding, anemia and frequent infections are the common symptoms. Multiple myeloma is diagnosed with the help of blood or urine tests or bone marrow biopsy. And the medication of multiple myeloma includes: Chemotherapy- There are several drugs that are used in the treatment of multiple myeloma such as doxorubicin, etoposide, cisplatin, cyclophosphami...
Read more