Is Carfilzomib a Chemotherapy Medicine? How it is Administered?


Carfilzomib is a type of chemotherapy medicine and a second-generation proteasome inhibitor. It is used to treat Multiple Myeloma, a B-cell malignancy in which there is an expansion as well as accumulation of abnormal plasma cells in the bone marrow, which accounts for 10% of all hematologic cancers. Plasma cells are found in the soft tissue inside bones known as bone marrow. They are an indispensable part of the immune system and form antibodies that fight and demolish foreign invaders. When an individual has MM, their plasma cells grow and progress out of control.

Carfilzomib injection is supplied under the brand name Kyprolis. It is a chemotherapy medicine that is widely used to treat individuals with relapsed or refractory multiple myeloma (RRMM):

  • along with dexamethasone or with lenalidomide plus dexamethasone in individuals who have previously received three therapies.
  • as a standalone medicine for those who received one or more therapies.

How Carfilzomib is Administration:

Carfilzomib (Kyprolis) for injection is administered as an intravenous (IV) infusion, which typically involves delivering the medicine directly into a vein via a needle. The carfilzomib infusion is given in a clinic, hospital, or health specialist`s office.

Carfilzomib is authorized for the treatment of relapsed or refractory multiple myeloma (RRMM) and may be administered on its own or along with dexamethasone or with lenalidomide plus dexamethasone.

The time span it takes to infuse carfilzomib typically depends on the dose regimen needed and varies from 10-30 minutes.

  • When injection carfilzomib 60 mg is administered on its own it is infused over either 10 or 30 minutes.
  • When carfilzomib is administered with the medicine dexamethasone it is infused over a period of 30 minutes.
  • When carfilzomib is administered with the medicine lenalidomide plus dexamethasone it is infused over a period of 10 minutes.

The number of carfilzomib 60 mg infusions you receive in a week mainly depends on the treatment combination being used. Carfilzomib may be given on 2 successive days or once weekly.

  • When Carfilzomib is administered on its own it is infused on 2 successive days each week.
  • When Carfilzomib is administered with dexamethasone it is given on either 2 successive days each week or once weekly.
  • When Carfilzomib is administered with the medicine lenalidomide plus dexamethasone it is infused on 2 successive days each week.

Tips for Before and After Carfilzomib Infusions: Consider these tips to help you practice good self-care both before and after the carfilzomib 60 mg injection.

Before Infusion:

  • Take it easy and rest
  • Drink water as water instructed by a health specialist
  • Coordinate your visit with a companion, in case one is available
  • Dress comfortably and wear loose-fitting, layered clothing

After Infusion:

  • Rest and recover, you might feel tired
  • Follow any special instructions given by the healthcare team
  • Share your experience by talking to your family, friends, and support communities

Reference:

https://www.kyprolis.com/what-to-expect#receiving-infusions


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