Indication and Usage of Ibrutinib



 Ibrutinib comes under the brand name Imbruvica. It is an anticancer medicine that belongs to a class of drugs called protein kinase inhibitors. The ibrutinib medication is available as immediate-release oral capsules and immediate-release oral tablets. Ibrutinib capsules for oral administration are available in the following dosage strengths: 70 mg and 140 mg. Although, ibrutinib tablets for oral administration are available in the following dosage strengths: 140 mg, 280 mg, 420 mg, and 560 mg.

 

Ibrutinib is used for the treatment of the following blood cancers in adults:

Mantle Cell Lymphoma: Ibrutinib is prescribed for the treatment of adult patients with MCL (mantle cell lymphoma) who have received at least 1-prior therapy.

 

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Ibrutinib is prescribed for the treatment of adult patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).

 

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with 17p deletion: Ibrutinib is prescribed for the treatment of adult patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) with 17p deletion.

 

Waldenström’s Macroglobulinemia: Ibrutinib is prescribed for the treatment of adult patients with Waldenström’s macroglobulinemia (WM).

 

Marginal Zone Lymphoma (MZL): Ibrutinib is prescribed for the treatment of adult patients with MZL (marginal zone lymphoma (MZL) who require systemic therapy and have received at least 1-prior anti-CD20-based therapy.

 

Chronic Graft versus Host Disease: Ibrutinib is prescribed for the treatment of adult patients with chronic graft-versus-host disease (cGVHD) after the failure of single or multiple lines of systemic therapy.

 

Mechanism of Action: In Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia, and Waldenström’s Macroglobulinemia, ibrutinib 140 mg capsule works by inhibiting the Bruton's tyrosine kinase, a protein in the body that favors these cancerous cells grow and survive. By inhibiting this protein, Ibrutinib helps kill and decrease the number of cancerous cells. This medication also resists the worsening of cancer.

 

Dosage: Ibrutinib dosage should be administered orally once daily with a glass of water at around the same time each day. Ibrutinib capsules or tablets need to be swallowed whole with water. It is not recommended to open, break, or chew the Ibrutinib capsules. Do not break or chew the tablets. This medication must not be taken with grapefruit juice. Ibrutinib should continue until the disease is progressive or no longer tolerated by the patient.

Comments

Post a Comment

Popular posts from this blog

Buy Trodelvy sacituzumab govitecan-hziy in India

  Trodelvy Overview: Trodelvy is widely prescribed by Oncologists for the treatment of patients with HR+/HER2- Metastatic Breast Cancer, Metastatic Triple-Negative Breast Cancer (mTNBC), and Metastatic Urothelial Cancer (mUC). It is considered a promising treatment option for those who are not ideal candidates for some conventional therapies. Developed by Immunomedics, Trodelvy 180 mg and Trodelvy 200 mg are two available commercial strengths. Worldwide, Trodelvy is promoted and facilitated by Gilead Sciences. Trodelvy is first approved on 22 April 2020. It is given by intravenous (IV) infusion by a health specialist. The medication received its (European Medicines Agency) EMA approval in October 2021. Trodelvy 180 mg and 200 mg injections are yet to be approved in India. The cost of Trodelvy in India usually depends on international factors. Buy Trodelvy from a Reliable Source: Many suppliers who are not authorized to handle or supply life-saving medicines such as Trodelvy found ...
Read more

Lenvatinib Medication Guide

Lenvatinib is recommended for treating patients with locally recurrent, progressive, metastatic, radioactive iodine-refractory differentiated thyroid cancer (RAI-refractory DTC), together with everolimus for advanced renal cell carcinoma and for hepatocellular carcinoma.  Here are a few important points for patients before taking Lenvatinib:- Female patients who are able to become pregnant must use an effective method of birth control while on the treatment with lenvatinib and for at least 2 weeks after its last dose. Discuss with your doctor about the birth control methods you can use during this time. Lenvatinib is taken at the same time each and every day. If a patient misses any dose, and it cannot be consumed within 12 hours, then that dose must be skipped and the next dose should be consumed at the usual time of administration. The recommended dose is lenvatinib 24 mg (two lenvatinib 10 mg capsules and one lenvatinib 4 mg capsule) orally, taken once in a day, either with or...
Read more

Difference Between Multiple Myeloma And Leukemia

Image
What is multiple myeloma:  This is also known as plasma cell myeloma or Kahler's disease. It is a cancer in plasma cells that typically produce antibodies. When there is only one tumor present it is called as plasmacytoma and when more than one then called as multiple myeloma. The main cause of myeloma is unknown but the major risk factors are obesity,  inheritance chemicals, radiation, etc. With the effect of cancer, there is an abnormality in plasma cells that produces abnormal antibodies that can cause kidney problems. At the initial stage, there is no sign and symptoms but with the advancement of time bone pain, bleeding, anemia and frequent infections are the common symptoms. Multiple myeloma is diagnosed with the help of blood or urine tests or bone marrow biopsy. And the medication of multiple myeloma includes: Chemotherapy- There are several drugs that are used in the treatment of multiple myeloma such as doxorubicin, etoposide, cisplatin, cyclophosphami...
Read more