Indication and Usage of Ibrutinib



 Ibrutinib comes under the brand name Imbruvica. It is an anticancer medicine that belongs to a class of drugs called protein kinase inhibitors. The ibrutinib medication is available as immediate-release oral capsules and immediate-release oral tablets. Ibrutinib capsules for oral administration are available in the following dosage strengths: 70 mg and 140 mg. Although, ibrutinib tablets for oral administration are available in the following dosage strengths: 140 mg, 280 mg, 420 mg, and 560 mg.

 

Ibrutinib is used for the treatment of the following blood cancers in adults:

Mantle Cell Lymphoma: Ibrutinib is prescribed for the treatment of adult patients with MCL (mantle cell lymphoma) who have received at least 1-prior therapy.

 

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Ibrutinib is prescribed for the treatment of adult patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).

 

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with 17p deletion: Ibrutinib is prescribed for the treatment of adult patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) with 17p deletion.

 

Waldenström’s Macroglobulinemia: Ibrutinib is prescribed for the treatment of adult patients with Waldenström’s macroglobulinemia (WM).

 

Marginal Zone Lymphoma (MZL): Ibrutinib is prescribed for the treatment of adult patients with MZL (marginal zone lymphoma (MZL) who require systemic therapy and have received at least 1-prior anti-CD20-based therapy.

 

Chronic Graft versus Host Disease: Ibrutinib is prescribed for the treatment of adult patients with chronic graft-versus-host disease (cGVHD) after the failure of single or multiple lines of systemic therapy.

 

Mechanism of Action: In Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia, and Waldenström’s Macroglobulinemia, ibrutinib 140 mg capsule works by inhibiting the Bruton's tyrosine kinase, a protein in the body that favors these cancerous cells grow and survive. By inhibiting this protein, Ibrutinib helps kill and decrease the number of cancerous cells. This medication also resists the worsening of cancer.

 

Dosage: Ibrutinib dosage should be administered orally once daily with a glass of water at around the same time each day. Ibrutinib capsules or tablets need to be swallowed whole with water. It is not recommended to open, break, or chew the Ibrutinib capsules. Do not break or chew the tablets. This medication must not be taken with grapefruit juice. Ibrutinib should continue until the disease is progressive or no longer tolerated by the patient.

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