Medical uses of Zoledronic Acid

Introduction: In 2001, Zoledronic acid was approved for medical use in the United States. It is also known as zoledronate. Zoledronic acid is a medication introduced for the treatment of several bone diseases. These include high blood calcium due to cancer, bone breakdown due to cancer, osteoporosis and Paget’s disease of bone. 

What is Zoledronic acid: Zoledronic acid is a bisphosphonate used in prevention of skeletal fractures in recipients with multiple myeloma and prostate cancer. This agent is also used for the treatment of osteoporosis. It may also be used for treating hypercalcemia of malignancy and can be effective in treating pain from bone metastases.

Zoledronic acid 4 mg can be administered at home rather than in hospital. Such use has shown safety and QoL benefits in recipients with breast cancer and bone metastases. 

Zoledronic acid injection may be administered as a 5 mg infusion once per year for treating male recipients with osteoporosis and women with post-menopausal at higher risk of fracture.

In the year of 2007, the USFDA also approved zoledronic acid injection for the treatment of recipients with postmenopausal osteoporosis.

Zoledronic acid may be used in the treatment of patients with osteogenesis imperfecta. A single 5 mg dose of zoledronic acid injection is used to treat Paget's disease.

How to Take Zoledronic acid: Zoledronic acid is given as an infusion into a vein. A healthcare professional usually administers this injection. Zoledronic acid is sometimes administered as a single dose only one time. The injection may also be administered once every one or two years. How often you receive zoledronic acid injection will depend on why you are using this bisphosphonate. Drink at least two glasses of water within a few hours before your injection to keep from getting dehydrated. You will also need certain frequent medical tests.

Price & Storage: The zoledronic acid price in India is quite reasonable at every certified (ISO and WHO-GDP) pharmaceutical wholesaler or pharmacy. Prices of zoledronic acid may vary depending on the non-branded to branded version drugs. 

Following the first opening, zoledronic acid injection should be used promptly. In case the solution is not used promptly, it should be stored in a refrigerator at temperature 2°C to 8°C but no longer than 24 hours.

Research: Findings suggest that the zoledronic acid injection has a direct antitumor effect and to synergistically augment the effects of other antitumor agents in the osteosarcoma cells.

This bisphosphonate (zoledronic injection) has demonstrated significant benefits vs placebo over 3 years, with a decreased number of vertebral fractures and enhanced markers of bone density. An annual zoledronic acid dose can also prevent recurring fractures in patients with a previous hip fracture.

Zoledronic acid injection is also involved in attenuating the accumulation of DNA damage in mesenchymal stem cells and protects their function. 

Note: The piece of information provided about "What are the medical uses of Zoledronic Acid" in this article is just for informational purposes and is not served as a substitute for the medical treatment, consultation, diagnosis, of an experienced/qualified doctor.

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