What are the medical uses of Methotrexate?

Methotrexate is used in order to treat gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. 

In acute lymphocytic leukemia, methotrexate is recommended in the prophylaxis of the meningeal leukemia and approved to be used in the maintenance therapy along with other chemotherapeutic agents. 

The methotrexate injection is also used in the treatment of meningeal leukemia. 

Methotrexate is approved to be used alone or together with other anticancer agents in order to treat breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell sorts. 

Methotrexate is also approved to be used together with other chemotherapeutic agents in order to treat advanced stage non-Hodgkin’s lymphomas. 

Methotrexate in high doses followed by leucovorin rescue along with the certain other chemotherapeutic agents is useful in the prolonging relapse-free survival in patients with non-metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor.

The methotrexate 50 mg injection is used in the symptomatic control of severe, recalcitrant, disabling psoriasis that is not adequately responsive to the other forms of therapy but only when the diagnosis has been established, as by biopsy or after the dermatologic consultation. 

Methotrexate is used in order to manage the selected adults with the severe, active RA, or children with the active polyarticular course juvenile rheumatoid arthritis, with insufficient therapeutic response to, or aren't tolerant of, an adequate trial of the first-line therapy including complete dose NSAIDs. 

Over the past 25 years, the methotrexate has become the standard of care in order to treat adults with rheumatoid arthritis. The numbers demonstrate that this medicine helps numerous individuals with RA. According to the National Rheumatoid Arthritis Society, over half of individuals with methotrexate see a 50 % improvement in the course of their disease. And over one-third of individuals see a 70 % improvement.

The methotrexate injection cost may vary depending on the wholesaler/pharmacy you visit and of course the brand choose. Apart from this, prices may also vary from innovator to generic drugs. Price for 1 g methotrexate injectable powder for injection is around 3,384 INR for a supply of 1 powder for injection. 


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