All About Voriconazole

voriconazole

Voriconazole is an antifungal drug. It is used to treat a variety of fungal infections (candida, aspergillosis) in the mouth (like thrush), esophagus, lungs, blood, and in other areas.

How should Voriconazole drug be taken: 

Voriconazole is existing as 200 mg and 50 mg tablets. During the first days of therapy, it can also be given by intravenous (I.V.: in the veins) injections. The intravenous injections will be given over a 1 to 2 hour period, likely by a nurse at the clinic.

Dose of voriconazole directly depends on the weight and also on the other drugs you are taking. The usual oral dosage is 200 mg twice daily.
This dose may need to be adjusted by your doctor to meet your needs.

Voriconazole tablets should be taken on an empty stomach. Take your dose at least 1 hour before or 2 hours after a meal.

Voriconazole tablets should be taken for the duration of time it is prescribed by your doctor.
In circumstances of earlier interruption, your infection may appear again. If the infection worsens or persists, consult your healthcare provider.

Adverse Reactions of Voriconazole: 

Voriconazole 200 mg may cause some stomach upset, nausea, vomiting, and loss of appetite.
Some other potential adverse effects are abdominal pain, diarrhea, and headache. If any of such signs or symptoms occur, please talk to your doctor Or healthcare team.

Voriconazole 200 mg can increase liver enzymes. This usually does not give any symptoms.
Rarely, hepatitis which is also known as an inflammation of the liver may occur. Signs of this are yellowing of the eyes and skin, fever, severe nausea or vomiting, dark urine, pale stools, fatigue, and abdominal pain. Consult a doctor immediately if you experience these adverse signs and symptoms. Your healthcare team will do regular blood tests in order to check the function of your liver.
Rarely, some people can develop an allergic reaction to voriconazole 200 mg . If you are allergic to the drug, you can develop a skin rash, hives, itching, swelling or tingling feeling in the mouth and throat, chest pain and tightness, and difficulties breathing. Please consult a doctor immediately if these symptoms appear.

Precautions: 
Before starting voriconazole 200 mg, please discuss with your healthcare team if you have ever suffered through an allergy to voriconazole or to some similar drugs such as ketoconazole (Nizoral), fluconazole (Diflucan), itraconazole (Sporanox).
Also notify your doctor if you have kidney, liver or vision problems.

Certain drugs have potential and they may be able to increase or decrease the effect of voriconazole. Also, voriconazole might affect or influence other drugs you are receiving. Discuss with your healthcare team about all the prescribed as well as non-prescribed drugs you consumed. If you are carrying an intention in order to initiate a new drug or any kind of natural product, please talk to your healthcare provider before doing so.

You should NOT take the following drugs if your doctor has prescribed voriconazole:
  • Carbamazepine (Tegretol) 
  • Efavirenz (Sustiva) standard dose 
  • Ergot derivatives
  • Phenobarbital 
  • Pimozide (Orap) 
  • Quinidine (Biquin Durules) 
  • Rifabutin (Mycobutin) 
  • Rifampin (e.g. Rifadin, Rimactane, Rofact) 
  • Ritonavir (Norvir) at doses of 400 mg twice daily or higher
  • Sirolimus (Rapamune) 
  • St. John’s Wort 
How should this drug be stored: Voriconazole should be stored at room temperature in a cool (15-30°C) dry place, protected from light and well out of the reach of children.
The diluted voriconazole solution for intravenous administration should be kept in the refrigerator between 2 to 8° C and used within 24 hours.

If you are receiving the intravenous solution at home, about an hour before your treatment, remove a bag from the refrigerator and let it warm to room temperature. Check your bag to ensure that there are no leaks and that there are no solid particles in the solution. If so, you should not use the bag.

Read:- Bosutinib and its uses.

Comments

Post a Comment

Popular posts from this blog

Buy Trodelvy sacituzumab govitecan-hziy in India

  Trodelvy Overview: Trodelvy is widely prescribed by Oncologists for the treatment of patients with HR+/HER2- Metastatic Breast Cancer, Metastatic Triple-Negative Breast Cancer (mTNBC), and Metastatic Urothelial Cancer (mUC). It is considered a promising treatment option for those who are not ideal candidates for some conventional therapies. Developed by Immunomedics, Trodelvy 180 mg and Trodelvy 200 mg are two available commercial strengths. Worldwide, Trodelvy is promoted and facilitated by Gilead Sciences. Trodelvy is first approved on 22 April 2020. It is given by intravenous (IV) infusion by a health specialist. The medication received its (European Medicines Agency) EMA approval in October 2021. Trodelvy 180 mg and 200 mg injections are yet to be approved in India. The cost of Trodelvy in India usually depends on international factors. Buy Trodelvy from a Reliable Source: Many suppliers who are not authorized to handle or supply life-saving medicines such as Trodelvy found to b
Read more

Trodelvy: All about the drug

Image
Indication and Usage The medicine Trodelvy is a Trop-2-directed antibody and topoisomerase inhibitor conjugate drug, which is used in the treatment of adults suffering from locally advanced or metastatic triple-negative breast (mTNBC) cancer, HR+/HER2- metastatic breast cancer, and locally advanced or metastatic urothelial cancer (mUC). It is used when it is not possible to remove cancer with surgery. Trodelvy  comes in the form of single-dose vials in 180 mg for intravenous infusion. Dosage Its dosage is based on body weight, and the recommended dosage is 10 mg/kg administered intravenously once weekly on the first day and eighth day of a repeating 21-day cycle. Administration First infusion: The drug is infused in the body for 3 hours, and during the infusion, the patient is observed for any adverse reaction caused by the infusion. After 30 minutes of infusion, observation should be done again to check for any post-infusion reaction. Subsequent Infusion: If the drug is tolerated in t
Read more

What is Non-Small Cell Lung Cancer? What are the stages of NSCLC?

Image
NSCLC, the most common form of lung cancer. It occurs when the healthy cells in the lung change and start growing in an abnormal way, forming a specific mass addressed as tumor, lesion, or nodule. A tumor may develop anywhere in the lung and could be cancerous or benign. A cancerous tumor mainly is malignant, means, it has potential in order to spread to the rest part of the body. A benign tumor is the tumor that can grow but can not spread.  Non-Small Cell Lung Cancer (NSCLC) occurs in the epithelial cells. Doctors can also describe this form of Cancer (NSCLC) based on the type of the epithelial cell where the cancer usually starts.  Adenocarcinoma starts in cells that produce mucus.  Squamous carcinoma basically developed in the cells that line the airways.  Large cell carcinoma usually begins in the cells other than the two types which are described above.  It’s necessary for healthcare providers to distinguish between lung cancer that begins in the squamous cells from lung cancer
Read more