All About Voriconazole

voriconazole

Voriconazole is an antifungal drug. It is used to treat a variety of fungal infections (candida, aspergillosis) in the mouth (like thrush), esophagus, lungs, blood, and in other areas.

How should Voriconazole drug be taken: 

Voriconazole is existing as 200 mg and 50 mg tablets. During the first days of therapy, it can also be given by intravenous (I.V.: in the veins) injections. The intravenous injections will be given over a 1 to 2 hour period, likely by a nurse at the clinic.

Dose of voriconazole directly depends on the weight and also on the other drugs you are taking. The usual oral dosage is 200 mg twice daily.
This dose may need to be adjusted by your doctor to meet your needs.

Voriconazole tablets should be taken on an empty stomach. Take your dose at least 1 hour before or 2 hours after a meal.

Voriconazole tablets should be taken for the duration of time it is prescribed by your doctor.
In circumstances of earlier interruption, your infection may appear again. If the infection worsens or persists, consult your healthcare provider.

Adverse Reactions of Voriconazole: 

Voriconazole 200 mg may cause some stomach upset, nausea, vomiting, and loss of appetite.
Some other potential adverse effects are abdominal pain, diarrhea, and headache. If any of such signs or symptoms occur, please talk to your doctor Or healthcare team.

Voriconazole 200 mg can increase liver enzymes. This usually does not give any symptoms.
Rarely, hepatitis which is also known as an inflammation of the liver may occur. Signs of this are yellowing of the eyes and skin, fever, severe nausea or vomiting, dark urine, pale stools, fatigue, and abdominal pain. Consult a doctor immediately if you experience these adverse signs and symptoms. Your healthcare team will do regular blood tests in order to check the function of your liver.
Rarely, some people can develop an allergic reaction to voriconazole 200 mg . If you are allergic to the drug, you can develop a skin rash, hives, itching, swelling or tingling feeling in the mouth and throat, chest pain and tightness, and difficulties breathing. Please consult a doctor immediately if these symptoms appear.

Precautions: 
Before starting voriconazole 200 mg, please discuss with your healthcare team if you have ever suffered through an allergy to voriconazole or to some similar drugs such as ketoconazole (Nizoral), fluconazole (Diflucan), itraconazole (Sporanox).
Also notify your doctor if you have kidney, liver or vision problems.

Certain drugs have potential and they may be able to increase or decrease the effect of voriconazole. Also, voriconazole might affect or influence other drugs you are receiving. Discuss with your healthcare team about all the prescribed as well as non-prescribed drugs you consumed. If you are carrying an intention in order to initiate a new drug or any kind of natural product, please talk to your healthcare provider before doing so.

You should NOT take the following drugs if your doctor has prescribed voriconazole:
  • Carbamazepine (Tegretol) 
  • Efavirenz (Sustiva) standard dose 
  • Ergot derivatives
  • Phenobarbital 
  • Pimozide (Orap) 
  • Quinidine (Biquin Durules) 
  • Rifabutin (Mycobutin) 
  • Rifampin (e.g. Rifadin, Rimactane, Rofact) 
  • Ritonavir (Norvir) at doses of 400 mg twice daily or higher
  • Sirolimus (Rapamune) 
  • St. John’s Wort 
How should this drug be stored: Voriconazole should be stored at room temperature in a cool (15-30°C) dry place, protected from light and well out of the reach of children.
The diluted voriconazole solution for intravenous administration should be kept in the refrigerator between 2 to 8° C and used within 24 hours.

If you are receiving the intravenous solution at home, about an hour before your treatment, remove a bag from the refrigerator and let it warm to room temperature. Check your bag to ensure that there are no leaks and that there are no solid particles in the solution. If so, you should not use the bag.

Read:- Bosutinib and its uses.

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