Health Care Knowledge

Introduction Semaglutide, a breakthrough medication in the field of diabetes management, has garnered significant attention in India due to its promising results and potential benefits for patients with type 2 diabetes. This article aims to provide an overview of semaglutide, including its indications, possible side effects, and pricing in the Indian market. Indications Semaglutide belongs to the class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). It is indicated as an add-on to exercise and diet to enhance glycemic control in adults suffering from  type 2 diabetes mellitus . The medication improves blood sugar control by increasing insulin release, decreasing glucagon secretion, and delaying gastric emptying. Side Effects Semaglutide  offers significant benefits for diabetes management, but it's essential to be aware of potential side effects. These can include: Nausea Vomiting Diarrhea Abdominal pain Constipation Weight loss These side effect...

Nitisinone received approval from both the US Food and Drug Administration (FDA) and the EU Agency in January 2002 and February 2005, respectively, for the treatment of patients with Hereditary Tyrosinemia type 1 (HT-1). Nitisinone can also be prescribed for the treatment of alkaptonuria (AKU) in adults.  The drug Nitisinone is currently formulated in dosage strengths of 2 mg, 5 mg, 10 mg, and 20 mg for oral use. Therapy should be administered as quickly as the diagnosis of HT-1 is confirmed. The recommended starting dose is 0.5 mg/kg twice daily. The highest approved oral dose is 2 mg/kg, administered orally twice daily. The capsule is administered either a couple of hours after meals or at least an hour prior to eating. This medicinal product must be administered with dietary restrictions of tyrosine and phenylalanine.  Nitisinone Availability and Sourcing Process: The medication Nitisinone is available in India. It is supplied both as a branded and generic version of the d...

Introduction Nitisinone is an inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, used to treat  hereditary tyrosinemia type 1  (HT-1). While it is an effective treatment, it comes with specific warnings and precautions that need to be considered to ensure patient safety and efficacy. Elevated Plasma Tyrosine Levels Nitisinone treatment may lead to elevated plasma tyrosine levels due to its inhibition of 4-hydroxyphenyl-pyruvate dioxygenase. To mitigate this risk, it is crucial to maintain a concomitant reduction in dietary tyrosine and phenylalanine. One should keep plasma tyrosine levels below 500 micromol/L to avoid adverse effects. One notable adverse effect of increased plasma tyrosine levels is the development of ocular symptoms, including corneal ulcers, opacities, and photophobia. Regular ophthalmologic examinations, especially slit-lamp examinations, should be performed before initiating Nitisinone treatment. If patients develop eye-related symptoms during treatment, i...

A drug called Semaglutide, which is sold under different brand names, was approved in 2017 to treat type 2 diabetes (T2D) and in 2021 (under a different brand name) for weight loss. This Type 2 diabetes medicine has become widely popular because of one of its side effects: weight loss.  Both the buzz and surge in demand for semaglutide have created a shortage of the medicine, according to the U.S. FDA, which is expected to remain the same for several months, causing alarm among those with diabetes who rely on  Semaglutide  to help manage their blood sugar level.  The non-diabetic individuals who are seeking slimmer waistlines are responsible for driving this growing demand. Experts caution that it’s crucial to understand Semaglutide is not a miracle medicine—and that there are risks to using the medicine outside of its intended use. Endocrinologist Gregory Dodell, based in Central Park Endocrinology, stated that I`ve noticed an increase in Semaglutide inquiries from ...